Primary hepatic carcinoma
Conditions
Interventions
trail group:none
control group:none
Sponsors
Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients with hepatocellular carcinoma complicated with intestinal dysfunction. (2) A history of hepatitis B cirrhosis. (3) Child-Pugh=8, ascites quantity was grade 1. (4) Aged 18-75, male or female, out-patient or inpatient in our department. (5) The course of disease is more than 6 months, and the patient has persistent abdominal discomfort or pain in the last 3 months, accompanied by at least 2 of the following characteristics: 1.Abnormal frequency of defecation (defecation >3 times a day or <3 times a week); 2.Abnormal fecal traits (lumpy/hard or watery stools); 3.abnormal fecal discharge process (effort, urgency, sense of exhaustion); 4.Mucinous stool; 5.Gastrointestinal flatulence or abdominal distension.
Exclusion criteria
Exclusion criteria: (1) The patient's Child-Pugh was C, or the BCLC stage was D. (2) The patient had moderate or large ascites or had upper gastrointestinal bleeding. (3) Used gastric acid inhibitors (proton pump inhibitors and H2 receptor antagonists), microbial agents, antibacterial drugs, metformin or non-absorbable disaccharides (such as lactilose) that affect intestinal flora, or targeted therapy drugs such as sorafenib, ramvaritinib and anlotinib within the last 4 weeks. (4) Patients with rheumatic immune diseases or systemic inflammation such as bacterial infection in the last 3 months. (5) White blood cells detected by routine stool microscopy were > 3 / high magnification field.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the intestinal microflora characteristics; | — |
Countries
China
Contacts
Public ContactCheng Binbin
Changhai Hospital
Outcome results
None listed