multiple system atrophy
Conditions
Interventions
control group:placebo
treatment group:Jiuwei Shengyang Prescription
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Meet the diagnostic criteria for MSA, including "possible" and "probable" MSA. 2 Meet OH diagnostic criteria. 3 Patients aged 30-80 years old, male and female. Participate in clinical study voluntarily and sign informed consent.
Exclusion criteria
Exclusion criteria: 1Use of vasoconstrictor drugs within 2 days prior to baseline. 2Persistent severe hypertension (systolic blood pressure =180mmHg or diastolic blood pressure =110mmHg) that cannot be relieved by antihypertensive drugs. 3Neurogenic orthostatic hypotension such as simple autonomic nerve failure, Parkinson's disease, lewy body dementia, diabetic autonomic nerve disorder. 4Orthostatic hypotension caused by cardiovascular diseases, adrenal dysfunction, hypovolemia and other non-neurogenic causes. 5 drug orthostatic hypotension caused by long-term regular use of tricyclic antidepressants (amitriptyline, etc.), diuretics (hydrochlorothiazide, furosemide, etc.) and prostate drugs (terazosin, tamsulosin, etc.). 6 Arrhythmia, including but not limited to sinus tachycardia (HR=90 beats/min), frequent atrial or ventricular premature beats, atrioventricular block, etc. 7 Patients with serious heart, brain, liver, kidney and other systemic diseases. 8Severe cognitive dysfunction, unable to cooperate with examination and treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Orthostatic hypotension symptom Checklist; | — |
Secondary
| Measure | Time frame |
|---|---|
| Balanced Confidence Scale;Mean values of orthostatic and decubitus blood pressure;Unified Multisystem Atrophy Score Scale; | — |
Countries
China
Contacts
Public Contactningxia
Outcome results
None listed