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Study on the mechanism of Qingchangxiaopi Decoction and UC large intestine damp-heat syndrome from the activation of LPDC through TLR5-IRF4 pathway to mediate intestinal inflammation

Study on the mechanism of Qingchangxiaopi Decoction and UC large intestine damp-heat syndrome from the activation of LPDC through TLR5-IRF4 pathway to mediate intestinal inflammation

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005909
Enrollment
Unknown
Registered
2022-04-26
Start date
2022-05-05
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative Colitis

Interventions

intervention group:Qingchangxiaopi Decoction

Sponsors

Dongguan Hospital of Guangzhou University of Chinese Medinine
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: ?The healthy subjects were inquired about medical history and physical examination, excluded cardiovascular and cerebrovascular diseases, diabetes, hypertension, hyperlipidemia and other medical history, and excluded intestinal organic diseases. ?UC patients who meet the diagnostic criteria; ?Meet the criteria for UC in the light to moderate activity period; ?Those who signed the informed consent.

Exclusion criteria

Exclusion criteria: ?Patients with severe heart, liver, kidney and other major organ diseases, hematopoietic system, nervous system or mental diseases; ?Patients with serious complications such as local stricture, toxic megacolon, intestinal obstruction, colon cancer, rectal cancer, intestinal perforation and anal disease; ?Reluctance to sign informed consent and collaborators.

Design outcomes

Primary

MeasureTime frame
Mayo score;

Secondary

MeasureTime frame
disease remission rate;single symptom treatment effect;erythrocyte sedimentation rate;High - sensitivity C - Reactive protein;The quality of life of inflammatory bowel disease questionnaire;

Contacts

Public ContactHuang Shaogang
huangshaogang@gzucm.edu.cn13926451320

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026