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Exploration of the Biological Characteristics in Patients with Different Chronic Liver Diseases Associated with Damp-heat Syndrome

The pathological basis of intestinal microecology in the damp-heat syndrome of non-alcoholic fatty liver disease

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2200005891
Enrollment
Unknown
Registered
2022-04-21
Start date
2019-01-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic liver disease

Interventions

Sponsors

Shuguang Hospital affiliated with Shanghai University of TCM
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Eligible patients with chronic liver diseases included those who were diagnosed with CHB or NAFLD, were 18–65 years of age, and signed an informed consent form.

Exclusion criteria

Exclusion criteria: Those who were diagnosed with other chronic liver diseases such as other viral hepatitis, alcoholic fatty liver disease, cirrhosis, liver cancer, and NAFLD co-infected with HBV were excluded. Those with serious primary disease or malignant tumor, who had undergone gastrointestinal bariatric surgery or taken weight loss drugs within the past three months, who had undergone gastrointestinal bariatric surgery in the past year or who had taken weight-loss drugs in the past 3 months and had lost more than 10% of their body weight, who had taken antibiotics or proton pump inhibitors within the past month, or were pregnant or lactating were also excluded. Healthy controls were defined as individuals with normal routine laboratory tests, no diagnosis of chronic liver disease, and no abnormal TCM symptoms.

Design outcomes

Primary

MeasureTime frame
hepatitis B virus marks antibody;AFP;traditional Chinese medical syndrom;HBV-DNA;kidney function;Faecl 16sRNA;HCG;liver function index;metabonomics index;Transcriptomics index;blood glucose;Abdominal ultrasound;blood lipids;

Countries

China

Contacts

Public ContactYiyang Hu

IRB of Shuguang Hospital affiliated with Shanghai University of TCM

yyhuliver@163.com+86 13916381584

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026