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A multicenter, double-blind, double-dummy, randomized controlled trial of the Chinese herbal medicine Linggui granule for patients with asthenospermia

A multicenter, double-blind, double-dummy, randomized controlled trial of the Chinese herbal medicine Linggui granule for patients with asthenospermia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005858
Enrollment
Unknown
Registered
2022-04-13
Start date
2022-08-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthenospermia

Interventions

control group:levocarnitine oral solution+Linggui granule mimetics
treatment group:Linggui granule and levocarnitine oral solution mimetics

Sponsors

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
22 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Study participants must meet the diagnostic criteria of male infertility. (2) Study participants must meet the diagnostic criteria of AZS. (3) Men aged 22 to 45 years (4) The participant must sign informed consent forms

Exclusion criteria

Exclusion criteria: (1)with infertility caused by organic lesions of the reproductive system (2)with infertility caused by the inability to complete sexual intercourse, including but not limited to erectile dysfunction, ejaculatory disorder (3)with reproductive system infection, such as chlamydia trachomatis or mycoplasma infection (4)with abnormal sex hormone (5)with palpable varicocele (6)with a history of allergy to any medicine or ingredients used in this study (7)complicated with mental diseases, malignant tumors, or serious organic diseases (8)use drugs affecting the experimental study within 3 months

Design outcomes

Primary

MeasureTime frame
PR sperm rate;

Secondary

MeasureTime frame
PR+NP sperm rate;spouse pregnancy rate;total effective sperm count;sperm DNA fragmentation index;

Countries

China

Contacts

Public ContactGuo jun
guojun1126@126.com010-62835134

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026