Chronic obstructive pulmonary disease
Conditions
Interventions
Treatment group 2:Tiotropium Bromide Powder for Inhalation+Shen Qi Bu Zhong prescription
Control group 1:Tiotropium Bromide Powder for Inhalation
Treatment group 3:Tiotropium Bromide Powder for Inhalation+Shen Qi Tiao Shen prescription
Control group 3: Tiotropium Bromide Powder for Inhalation
Treatment group 1:Tiotropium Bromide Powder for Inhalation+Shen Qi Wen Fei prescription
Control group 2:Tiotropium Bromide Powder for Inhalation
Sponsors
The First Affiliated Hospital of Anhui University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? Patients who meet the diagnostic criteria for COPD; ? It belongs to stable period; ? It conforms to the TCM syndrome differentiation standard of lung qi deficiency/Lung spleen qi deficiency/lung kidney qi deficiency; ?40 years = age =75 years; ? Did not participate in other clinical studies 3 month before enrollment; ? No antibiotics were used 3 month before enrollment; ? Voluntarily accept treatment, sign informed consent before the test, and fully understand the content, process and possible adverse reactions of the test.
Exclusion criteria
Exclusion criteria: If the answer to any of the following questions is "yes", the patient will not be admitted to the study: ? Allergic constitution or allergic to the known ingredients of the test drug or control drug; ? Extremely severe COPD patients and acute stage patients; ? Pregnant and lactation women; ? Delirious, dementia, all kinds of mental patients; ? Functional grade ? and hemodynamic instability; ? With bronchiectasis, bronchial asthma, active pulmonary tuberculosis, pulmonary embolism, pneumothorax, pleural effusion, malignant tumor and other neuromuscular diseases affecting respiratory motor function;? Severe liver and kidney disease (severe liver disease refers to cirrhosis, portal hypertension and varicose bleeding, serious kidney disease including dialysis, kidney transplantation); ? all kinds of reasons for long-term bed. ? Persons who have participated in other interventional clinical trials within the last 3 months; ? Participants considered unsuitable for the clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung function;Acute aggravation severity;Number of acute exacerbations;TCM syndrome integral;Number of colds; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnea classification;SF-36 scale;COPD - PRO scale;Self-rating Depression Scale;Self-rating Anxiety Scale;The CAT score;Six minutes' walk; | — |
Countries
China
Contacts
Public ContactLi Zegeng
Anhui University of Chinese Medicine
Outcome results
None listed