chronic spontaneous urticaria
Conditions
Interventions
Intervention group:Piminxiao Capsule and Levcetirizine
Control group:Piminxiao Capsule
Sponsors
Jiangsu Province Hispital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Participants are included if they are aged between 18 and 60 years; clinically diagnosed with CSU, and belonging to wind-heat or wind-heat complicated by dampness according to TCM; and give written informed consent. For the diagnostic criteria of CSU, we will refer to The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis and management of urticaria. For the TCM diagnostic criteria, we will refer to Expert Consensus on TCM Treatment of Urticaria.
Exclusion criteria
Exclusion criteria: 1. Patients with obvious predisposing factors can be found (such as cold urticaria, stress urticaria, etc. ). 2. Patients with other diseases with urticaria or vascular edema as skin manifestations, such as hereditary vascular edema, acquired vascular edema. 3. Interventions of glucocorticoid, hydroxychloroquine, methotrexate, cyclophosphamide, cyclosporine or intravenous immunoglobulin in the previous 1 month. 4. Interventions of histamine H2 receptor antagonist or leukotriene receptor antagonist in the previous 1 week. 5. Patients who took off-label dosage levocetirizine hydrochloride or used other histamine H1 receptor antagonists in the last two weeks 6. Patients allergic to the drugs used in this study. 7. Patients with serious primary diseases of the liver or kidney systems. 8. Patients with pregnancy or lactation. 9. Other conditions that researchers believe are unsuitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urticaria activity score, UAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic Urticaria Quality of Life Questionnaire, CU-Q2oL;TCM symptom scale score;Itch severity score, ISS;Urticaria control test, UCT; | — |
Countries
China
Contacts
Public ContactHong Shengwei
Outcome results
None listed