heart failure with preserved ejection fraction
Conditions
Interventions
test group:Conventional treatment + Shengui capsules
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Patients with heart failure with preserved ejection fraction who meet the diagnostic criteria and have symptoms who need diuretics and whose cardiac function class (NYHA class) is II to IV; ?Meet the 2019ESC diagnostic criteria for chronic coronary syndrome ? The cause of heart failure in patients with preserved ejection fraction is caused by coronary heart disease; ?Traditional Chinese medicine for heart failure patients with heart-yang insufficiency, qi deficiency and blood stasis; ? Those who received at least 2 weeks of standardized western medicine treatment and reached the optimal dose; ? Those who have not used traditional Chinese medicine/proprietary Chinese medicine for the treatment of heart failure within 2 weeks before enrollment; ?Age between 40-80 years old; ? Those who are in good spirits and able to communicate verbally and in writing; ? The HFpEF patients who signed the informed consent form voluntarily participated in this study.
Exclusion criteria
Exclusion criteria: ? Under stable conditions, any previous echocardiographic measurement of LVEF = 50%; ? Acute decompensated heart failure within 30 days prior to screening, or acute coronary syndrome (including myocardial infarction), cardiac surgery, other major cardiovascular surgery, or emergency percutaneous coronary intervention within 3 months prior to screening interventional therapy; ? At the time of screening, walking distance was mainly limited by non-cardiac disease; ? History of dilated cardiomyopathy, including perinatal cardiomyopathy, chemotherapy-induced cardiomyopathy or viral myocarditis; ? History of hypertension and poor blood pressure control (systolic blood pressure = 160 mmHg, or diastolic blood pressure = 100 mmHg); ? Patients with glycated hemoglobin>7.5% did not receive diabetes treatment; ? Patients with serious primary diseases such as lung, brain, liver, kidney, hematopoietic system, mental illness, and severe neurosis; ? Patients with Yin deficiency and Yang Sheng with symptoms such as burning skin, five upset hearts, shortness of breath, and constipation; ?Allergic constitution or allergic to known components of the test drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| KCCQ;six-minute walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| echocardiography;NT-proBNP; | — |
Countries
China
Contacts
Public ContactChang Peifen
Outcome results
None listed