cognitive aging
Conditions
Interventions
Long-term Irregular exercise group:no
Long-term regular Tai Chi exercise group:Tai chi
Sponsors
Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1)Long-term regular Tai Chi exercise group: ? Gender is not limited, and the age range from 60 to 75 years old; ? At least 6 years of education; ? Long-term regular Tai Chi exercise for at least 6 years, 3 time per week, and more than 30min each time; ? Right-handed; ? Normal cognitive function (MoCA scale score = 26 points); ? Subjects are informed and volunteer to sign informed consent. (2)Long-term no exercise group: ?Gender is not limited, the age range from 60 to 75 years old, and the proportion matches the age, gender and education level of the long-term regular Tai Chi group; ? At least 6 years of education; ? At least 6 years of irregular physical exercise (such as traditional sports, jogging, yoga, meditation, brisk walking, etc.), exercise < 3 times a week, and each session < 30 minutes; ? Right-handed; ? Normal cognitive function (MoCA scale score = 26 points); ? Subjects are informed and volunteer to sign informed consent.
Exclusion criteria
Exclusion criteria: ? Have neurological diseases (such as stroke, Parkinson's, epilepsy or dementia), history of mental illness, history of traumatic brain injury, history of brain mass, etc.; ? Those with uncontrollable hypertension (systolic blood pressure =160mmHg or diastolic blood pressure =100mmHg after taking the drug), and those with diabetes mellitus (HbA1c>8%); ? Are taking or have taken drugs that affect the nervous system or psychosis within 2 weeks ? Depressed patients, the geriatric depression scale> 5 points; ? Patients with implanted metal substances (such as metal dentures, pacemakers, etc.), space claustrophobia and other patients who are not suitable for MRI; ? Those who have visual/hearing impairment or writing/reading impairment that cannot cooperate to complete the assessment; ? Those who are participating in other research trials that affect the results of this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| executive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum exosomes;changes in brain structure and functional connectivity;electroencephalogram patterns;dual-task gait;Brain activity;Balance function;attention;memory; | — |
Countries
China
Contacts
Public ContactChenlidian
Outcome results
None listed