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Clinical study and molecular mechanism of Piwei Peiyuan recipe in the treatment of chronic atrophic gastritis with intestinal metaplasia

Clinical study and molecular mechanism of Piwei Peiyuan recipe in the treatment of chronic atrophic gastritis with intestinal metaplasia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005779
Enrollment
Unknown
Registered
2022-03-28
Start date
2022-04-30
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic atrophic gastritis with intestinal metaplasia

Interventions

treatment group: Piwei Peiyuan Prescription
control group:folic acid tablet

Sponsors

Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Age: 18-70 years old, no gender limitation; (2) It conforms to the diagnostic criteria of chronic atrophic gastritis with intestinal metaplasia and TCM syndrome of spleen and stomach weakness; (3) Hp negative patients or previous Hp infection, successful eradication treatment for more than six months and no symptomatic infection; (4) Those who voluntarily participate in the clinical trial and give informed consent and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) complicated with peptic ulcer, pathologically confirmed as high-grade intraepithelial neoplasia or suspected malignant transformation; (2) have a history of severe digestive diseases or abdominal surgery; (3) pregnant and lactating women; (4) serious diseases associated with the study evaluation, such as severe blood diseases, liver disease, heart disease, kidney disease, malignant tumor, etc.; (5) patients with disabilities as prescribed by law; (6) Long-term use of NSAIDS and history of alcoholism; (7) allergic to drugs used in this study; (8) Participants in clinical trials of other drugs in the last 4 weeks; Or have used mofuchun, morodane, folic acid and other preparations in recent 2 weeks; (9) Easy to cause lost visitors.

Design outcomes

Primary

MeasureTime frame
pathological diagnosis;The pathological integral;

Secondary

MeasureTime frame
TCM syndrome Integral;Results of gastroscopy;life quality score;serological indicator;Anxiety indicators;

Countries

China

Contacts

Public ContactLi Xuejun

Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine

lixuejun0308@126.com0551-62668504

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026