Dyslipidemia with carotid artery plaque
Conditions
Interventions
Sponsors
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with 50% carotid stenosis and 50%-69% carotid stenosis were selected, The diagnostic criteria for carotid artery stenosis refer to Carotid Artery Stenosis: Gray-Scale and Doppler US Diagnosis--Society of Radiologists in Ultrasound Consensus Conference; 2. Patients with dyslipidemia were selected, The diagnostic criteria for dyslipidemia refer to Guidelines for the prevention and treatment of dyslipidemia in adults in China (2016 revision),or biochemical assay of patients: TG >= 2.30mmol/L; 6.11mmol/L <= TC; 3.37mmol/L <= LDL-C; Any one of the above indicators is abnormal and TC < 7.2mmol/L, LDL-C<4.9mmol/L can be included in the group; 3. The TCM syndrome type is phlegm and blood stasis block syndrome; 4. Aged 25-80 years; 5. Voluntarily participate in this clinical study and sign the informed consent form, insist on taking the medicine for 8 weeks, and complete the pre-treatment and post-treatment scale filling, blood test examination, and a fixed contact information to complete the follow-up work.
Exclusion criteria
Exclusion criteria: 1. Dyslipidemia caused by hypothyroidism, gout and nephrotic syndrome; patients with homozygous familial hypercholesterolemia; dyslipidemia caused by acute and chronic hepatobiliary diseases; Dyslipidemia caused by blockers, adrenal corticosteroids and some contraceptives, etc.); 2. Patients with serious primary diseases such as liver, kidney and hematopoietic system and mental illness; 3. Patients with hypertension grade III, acute coronary syndrome and cardiac function grade III-IV; patients with acute myocardial infarction, cerebrovascular accident, severe trauma or major surgery within 0.5 years; pregnant or lactating women; allergic constitution and allergic to the test drug; 4. Ultrasound showed that the plaque caused the carotid artery lumen stenosis >=70%, which seriously affected the carotid artery blood flow.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical assay (TC, TG, LDL-C, HDL-C);Between-group differences in the annualized change in mean IMT of 12 sites of bilateral carotid arteries;Major cardiovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events;life quality evaluation;Vascular remodeling index;inflammatory cytokine (IL-6, TNF-10, hs-CRP);Maximal plaque area; | — |
Countries
China
Contacts
Public ContactHe Qingyong
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed