Breast Cancer
Conditions
Interventions
Experimental group:Oral Ruaishuhou prescription and Yishentiaogan prescription
Control group:Oral Add and subtract Ruaishuhou prescription
Sponsors
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65; 2. Patients diagnosed as breast cancer by pathology and HR positive by immunohistochemistry; 3. Completed surgery, chemotherapy, radiotherapy, and/or targeted therapy; 4. Have received AIs (anastrozole, Letrozole, exemestane) for at least 2 months; 5. TCM syndrome differentiation belongs to liver and kidney deficiency (symptoms include tenderness of waist and knee, stiffness of joints, dizziness, etc.); 6.KPS score =60; 7. The expected survival is more than 6 months; 8. Signed the informed consent and voluntarily accepted the treatment plan of the study.
Exclusion criteria
Exclusion criteria: 1. Bone mineral diseases: such as hypoparathyroidism or hyperthyroidism, malformed osteitis, osteogenesis imperfection, osteomalacia, etc.; 2. Diseases that affect bone metabolism, such as Cushing's syndrome, hyperthyroidism, rheumatism or rheumatoid arthritis; 3. Steroid hormones or anticonvulsants were used for more than 6 months before the study; 4. Used hormone replacement therapy within 6 months, such as glucocorticoid, parathyroid hormone, estrogen, etc.; 5. Had surgery related to extremities within 6 months; 6. Complicated with serious primary diseases of cardiovascular, liver, kidney and hematopoietic systems; 7. Patients with obvious disease progression and distant metastasis during the study; 8. Psychopaths with cognitive impairment or mental abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone density test;TCM symptom and sign scoring;Growth hormone(GH);Bone metabolism indicators (25-Hydroxy-vitamin-D, ß-CTX, osteocalcin); | — |
Countries
China
Contacts
Public ContactCHEN HONGFENG
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed