Exploratory clinical study on DNA methylation difference of whole gene in coronary heart disease patients with heat-toxin and blood-stasis syndrome and cold-coagulation and blood-stasis syndrome

To explore the mechanism of promoting blood circulation and detoxifying Traditional Chinese medicine Zhizi Chuanxiong capsule on atherosclerosis from DNA methylation and downstream MAPK signaling pathway

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ITMCTR

Registry ID

ITMCTR2200005725

Enrollment

Unknown

Registered

2022-03-15

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary atherosclerotic heart disease

Interventions

Group of coronary heart disease with heat toxin blood stasis syndrome:none

Normal control group:none

Group of CHD patients with cold coagulation and blood stasis syndrome:none

Eligibility

Sex/Gender

All

Age

30 Years to 75 Years

Inclusion criteria

Inclusion criteria: ? Age from 30 to 75, no gender limitation; ? Patients with stable angina or unstable angina with coronary angiography and/or coronary CT confirmed at least one coronary artery stenosis =50% or with a clear history of myocardial infarction. Coronary angiography results were confirmed by 2 physicians with professional titles above deputy director; ? Patients with heat-toxin and blood-stasis syndrome and cold-coagulation and blood-stasis syndrome in TCM syndrome type diagnostic criteria. ? Sign informed consent.

Exclusion criteria

Exclusion criteria: Those who possess any of the following are excluded: ? Congenital heart disease, cardiomyopathy, coronary spasm, severe cardiopulmonary insufficiency (heart function above grade III, severe lung insufficiency); ? patients with acute cerebrovascular disease; ? Patients with hypertension and poor blood pressure control (systolic blood pressure = 180mmHg, diastolic blood pressure = 110mmHg); ? Complicated with chronic inflammatory diseases, severe infection, diabetes and poor blood glucose control, malignant arrhythmia, malignant tumor and multiple organ failure; (5) with serious primary diseases such as liver, kidney and hematopoietic system, mental disorders can not express their will correctly and communication disorders; ? Patients who are participating in clinical trials of other drugs; ? Pregnant or lactating women; ? Alcoholism and drug abuse and addiction.

Design outcomes

Primary

Measure	Time frame
Routine urine test;RNA transcriptome;Electrocardiogram (ecg);Liver and kidney function tests;Haematology;DNA methylation;Coagulation function test;	—

Countries

People's Republic of China

Contacts

Public ContactFengqin Xu

zhouqingbing0910@163.com18800021979

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026