hypertension accompanied by anxiety
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Anyone who meets the following criteria at the same time can be included: 1. The age is more than 18 years old and less than 90 years old, and the gender is not limited; 2. Meet the above diagnostic criteria for hypertension associated with anxiety; 3. Hamilton Anxiety Scale (HAMA) (14-item version) (7 points to 14 points), Self-Rating Anxiety Scale (SAS) (50 points to 59 points); 4. The patient has clear thinking, normal comprehension, and no mental illness; 5. Patients gave informed consent to this study, cooperated voluntarily, had good compliance, and signed an informed consent form.
Exclusion criteria
Exclusion criteria: Those who meet any of the following will not be included: 1. Those who are participating in other clinical trials; 2. Subjects suffering from diarrhea, ulcerative colitis, Crohn's disease or other infectious diseases; 3. Take antibiotics, steroid hormones or probiotics 3-6 months before sampling; 4. Significant changes in diet one week before sampling; 5. Complicated with serious organic diseases such as tumors, blood diseases, organ failure, etc.; 6. Those who have received psychiatric treatment and have been taking anti-anxiety and depression drugs for a long time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| short chain fatty acids;Generalized Anxiety Disorder Scale;Norepinephrine;trimethylamine oxide;Hamilton Anxiety Scale;adrenocorticotropic hormone;Homocysteine;Angiotensin II;Cortisol;serotonin;Glucocorticoids;GABA;dopamine;corticotropin-releasing hormone;Renin;Catecholamines;Aldosterone;Adrenomedullin;endothelin 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| reactive oxygen species;Lipopolysaccharide;Nitric oxide;interleukin-1; | — |
Countries
CHINA