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Based on the gut microbiota-gut-brain axis to explore the clinical and mechanism of five-element music in the treatment of hypertension accompanied by anxiety

Based on the gut microbiota-gut-brain axis to explore the clinical and mechanism of five-element music in the treatment of hypertension accompanied by anxiety

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005718
Enrollment
Unknown
Registered
2022-03-15
Start date
2022-03-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension accompanied by anxiety

Interventions

five-element music group:Antihypertensive drugs plus five-element music

Sponsors

The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Anyone who meets the following criteria at the same time can be included: 1. The age is more than 18 years old and less than 90 years old, and the gender is not limited; 2. Meet the above diagnostic criteria for hypertension associated with anxiety; 3. Hamilton Anxiety Scale (HAMA) (14-item version) (7 points to 14 points), Self-Rating Anxiety Scale (SAS) (50 points to 59 points); 4. The patient has clear thinking, normal comprehension, and no mental illness; 5. Patients gave informed consent to this study, cooperated voluntarily, had good compliance, and signed an informed consent form.

Exclusion criteria

Exclusion criteria: Those who meet any of the following will not be included: 1. Those who are participating in other clinical trials; 2. Subjects suffering from diarrhea, ulcerative colitis, Crohn's disease or other infectious diseases; 3. Take antibiotics, steroid hormones or probiotics 3-6 months before sampling; 4. Significant changes in diet one week before sampling; 5. Complicated with serious organic diseases such as tumors, blood diseases, organ failure, etc.; 6. Those who have received psychiatric treatment and have been taking anti-anxiety and depression drugs for a long time.

Design outcomes

Primary

MeasureTime frame
short chain fatty acids;Generalized Anxiety Disorder Scale;Norepinephrine;trimethylamine oxide;Hamilton Anxiety Scale;adrenocorticotropic hormone;Homocysteine;Angiotensin II;Cortisol;serotonin;Glucocorticoids;GABA;dopamine;corticotropin-releasing hormone;Renin;Catecholamines;Aldosterone;Adrenomedullin;endothelin 1;

Secondary

MeasureTime frame
reactive oxygen species;Lipopolysaccharide;Nitric oxide;interleukin-1;

Countries

CHINA

Contacts

Public ContactHONG CHUANGXIONG
hongchuangxiong@gzucm.edu.cn13802763281

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026