influenza
Conditions
Interventions
Experimental group:Oseltamivir phosphate granules + antipyretic granules
The control group:Oseltamivir phosphate granules
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Meet the western diagnostic criteria for influenza; 2. Out-patient children with the course of disease within 48 hours; 3. Conforming to the syndrome differentiation standard of TCM wind-heat syndrome; 4. Aged from 3 to 12; 5. The informed consent process is in accordance with the provisions, and the legal representative or the subject child (=8 years old) jointly signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe or critical cases of influenza; 2. Antiviral drugs were used within 48 hours before this visit; 3. Children with chronic and serious underlying diseases; 4. Children with intolerance to study drugs; 5. The researcher thinks that the person is not suitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse events/reactions occurred during treatment were recorded;CARIFS symptom dimension score and its area under the curve relative to time;Disappearance rate of single symptom;Hospitalization rates;Use rate of antifebrile drugs;Vital signs (temperature, respiration, heart rate, blood pressure), blood routine, urine routine, ELECTROcardiogram, liver function (ALT, AST, ALP), kidney function (BUN, Cr);Curative effect of TCM syndromes (cure rate);Influenza virus nucleic acid negative conversion rate;Time of antipyretic effect;Time for complete fever reduction;Duration of immediate fever reduction; | — |
Countries
China
Contacts
Public ContactJianshe Wang
Outcome results
None listed