Varicocele
Conditions
Interventions
experimental group:Yishen Tongluo Formula on Varicose spermatic vein
Sponsors
Henan Province Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine)
Eligibility
Sex/Gender
Male
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: ?In line with the 2015 Chinese expert consensus on the diagnosis and treatment of varicocele [1], and one of the following conditions; ?infertility;abnormal semen quality;The woman has normal fertility, or has a related disease that causes infertility but may be cured; ?Abnormal semen quality is found by examination,although there is no requirement for fertility; ?The related symptoms associated with varicocele (such as perineal or testicular bulging pain, etc.) are more serious and significantly affect the quality of life,and the conservative treatment does not improve significantly ?The serum testosterone level of grade ? or ? varicocele decreased significantly excluding other diseases References[1]:Chun-Hua Deng,Xue-Jun Shang.Chinese expert consensus on the diagnosis and treatment of varicocele.Zhonghua Nan Ke Xue.2015;21(11):1035-42.
Exclusion criteria
Exclusion criteria: ?Secondary varicocele, including left renal vein nutcracker syndrome, abdominal and retroperitoneal tumor compression and other causes; ?Combined with severe liver and kidney insufficiency, hypertension, diabetes, abnormal coagulation function, etc; ?Combined with previous history of spermatic vein surgery and postoperative recurrence; ?Combined with Azoospermia ?Combined with congenital developmental abnormalities, genetic or psychiatric disorders, neurological disorders; ?Combined with retrograde ejaculation, erectile dysfunction, testicular atrophy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole exome testing(WES) was used to detect mutated genes in patients with varicocele;RNA-seq on varicose vein endothelial cells followed by qRT-PCR verification;Expression of cyclinD2, PCNA, caspase-3 and survivin protein in varicose vein endothelial cells;Expression of p-PI3K, p-AKT, p-mTOR, Beclin1, IGF-1 protein in varicose vein endothelial cells; | — |
Countries
China
Contacts
Public ContactXun Li
Outcome results
None listed