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The mechanism of Cangfu Daotan Decoction in polycystic ovary syndrome based on NEK7-NLRP3 inflammasome signaling pathway

Study on TCM Syndrome of Phlegm-Dampness PCOS Infertility Based on Follicular Fluid Proteomics

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005611
Enrollment
Unknown
Registered
2022-02-07
Start date
2022-02-07
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Interventions

Three:Cangfu Daotan Decoction

Sponsors

Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Phlegm-damp type PCOS patients ?In line with the diagnostic criteria of Chinese and Western medicine for phlegm-damp PCOS; ?Body Mass Index (BMI) = 27kg/m2; ?Age between 20 and 35 years old; ?Have signed the informed consent. 2. Non-phlegm-damp PCOS patients ?Comply with the western medicine diagnostic standards of PCOS; ? BMI is 18~26kg/m2; ?Age between 20 and 35 years old; ?Have signed the informed consent. 3. Normal control group patients ? Those who practice assisted reproductive technology due to male factors; ?BMI is 18~26kg/m2; ?Age between 20 and 35 years old; ?Have signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Age 35 years old; 2. Suffering from other diseases that can cause ovulation disorders or hyperandrogenism, such as hyperprolactinemia, Cushing's syndrome, congenital adrenal hyperplasia, etc.; 3. Combined with other systemic diseases and inflammatory diseases, such as diabetes, hyperthyroidism, heart disease, etc.; 4. Those with a history of recurrent miscarriage;

Design outcomes

Primary

MeasureTime frame
caspase-1;apoptosis - associatedspeck-like protein containing a CARD(ASC);IL-18;IL-1b;pyrin domain containing 3 (NLRP3);NEK7;

Secondary

MeasureTime frame
Body Mass Index(BMI);anti-Müllerian hormone(AMH);Luteinizing hormone(LH);follicle stimulating hormone(FSH);testosterone(T);

Countries

China

Contacts

Public ContactLian Fang
lianfangbangong@163.com13706403122

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026