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To explore the efficacy and mechanism of Fuyang Jieyu therapy in treating depression disorder with deficiency syndrome based on acid retention, canine urine metabolic pathway and DNA methylati

To explore the efficacy and mechanism of Fuyang Jieyu therapy in treating depression disorder with deficiency syndrome based on acid retention, canine urine metabolic pathway and DNA methylati

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005599
Enrollment
Unknown
Registered
2022-02-04
Start date
2022-02-07
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression disorder

Interventions

Western Medicine group:taking SSRI or SNRIS antidepressants
healthy control group:none
traditional Chinese medicine group:taking traditional Chinese medicine

Sponsors

First Affiliated Hospital of Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Inclusive criteria for the depression disorder with deficiency syndrome group were as follows: (1) Current symptoms met the diagnosis of depression according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th revision) (2) According to Diagnosis of Traditional Chinese Medicine, deficiency syndrome can be identified from the course of disease, constitution, spirit, voice, pain, distension of chest and abdomen, fever, aversion to cold, tongue, pulse and other aspects (3) Not caused by psychoactive substances or organic diseases (4) 16 years old = age = 60 years old. 2.Inclusion criteria for the healthy group were as follows: (1) a good health record, no physical illness and psychiatric disorder (2) Results have been normal in this examination (3) no sleeping disorders and digestive dysfunction (4) No history of infection, alcohol intake, taking diuretics, antacids, acidulants and drugs that can affect gastrointestinal absorption or renal acid excretion within the previous week

Exclusion criteria

Exclusion criteria: Exclusion criteria for the depression disorder with deficiency syndrome group were as follows: (1) abuse of alcohol and psychoactive substances (2) A previous episode of mania or hypomania that met symptom criteria (3) pregnant or lactating female patients (4) presence of obvious cardiovascular system, respiratory system, liver, kidney, diabetes and other physical diseases (5) patients who took diuretics, antacids, acidulants and drugs that can affect gastrointestinal absorption or renal acid excretion in the previous week (6) infection history within the past week (7) patients confined to wheelchairs

Design outcomes

Primary

MeasureTime frame
the score of HAMA;venous blood gas analysis;active metabolites of kynurenine metabolic pathway;renal acidification function;the score of HAMD-17;DNA methylation;—

Countries

China

Contacts

Public ContactHaoying Hu
hyhu15@126.com15360868505

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026