Randomized controlled study of modified Qingre Lishi Decoction and antibiotics in the treatment of chronic endometritis

A multicenter, randomized, controlled study was conducted on the efficacy between traditional Chinese medicine and antibiotics in the treatment of chronic Endometritis women who is 18 to 40 years

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2200005503

Enrollment

Unknown

Registered

2022-01-05

Start date

2022-01-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Endometritis

Interventions

Research Group:Qingre Lishi Decoction

Control group:antibiotic

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Age: women of childbearing age, 18-40 years. (2) Diagnosis of CE by endometrial histopathological CD138 immunohistochemical testing; diagnostic criteria: =1 CD138-positive cells/10 HPF. (3) TCM syndrome type of Qi deficiency, dampness and heat. (4) Voluntarily signed written informed consent. (5) Histopathological diagnosis not suggestive of endometrial hyperplasia and endometrial cancer. (6) willing to undergo repeat hysteroscopy and endometrial histopathological examination to evaluate CE regression.

Exclusion criteria

Exclusion criteria: (1) Received estrogen or progestin treatment within 1 month. (2) Received Chinese herbal medicine and antibiotics within 1 month. (3) History of allergy to Chinese herbal ingredients and antibiotics in addition to Qinghelian Dampness Soup. (4) other medical indications requiring antibiotic treatment before re-hysteroscopy and histopathological examination of the endometrium. (5) Cases requiring estrogen and progestin due to medical condition. (6) Pregnancy status and pregnancy-related diseases. (7) No randomized grouping was accepted.

Design outcomes

Primary

Measure	Time frame
Endometrial CD138 Negative conversion rate;	—

Secondary

Measure	Time frame
Hysteroscopy microscopic features;Endometrial CD56;	—

Countries

China

Contacts

Public ContactDongmei Song

Department of Hysteroscopic Centre, Fuxing Hospital, the Eighth Clinical Medical College, Capital Medical University, Beijing

echosdm@163.com010-88062220

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026