Diabetic encephalopathy cognitive dysfunction
Conditions
Interventions
placebo group:given patients placebo that had no therapeutic effect
BH group:Give patients buyang huanwu decoction
Sponsors
The first hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 55 to 75 met the diagnostic criteria for T2DM formulated by WHO in 1999; (2) HbA1c range: 6.5-9%; (3) Conforming to the criteria of TCM syndrome differentiation (4) Montreal Cognitive Assessment Scale (MoCA) score <26 points, complex instrumental daily ability may be slightly impaired, daily living ability normal, does not meet the diagnostic criteria for dementia (5) Able to communicate well with researchers and comply with the requirements of the whole experiment. (6)Other causes of cognitive dysfunction have been ruled out.
Exclusion criteria
Exclusion criteria: (1) New diseases that may cause blood glucose changes within 3 months, such as infection, myocardial infarction, tumor, inflammation, trauma and other severe stress states, as well as hyperthyroidism, hypothyroidism, hypercortisolism and acromegaly; (2) Cognitive impairment caused by taking drugs that raise blood glucose or improve cognition or neuropsychiatric drugs within 3 months. (3) severe liver disease (including chronic persistent hepatitis, cirrhosis or simultaneous hepatitis B virus surface antigen positive and abnormal liver transaminase (serum alanine aminotransferase or aspartate aminotransferase concentration > 2.5 times the normal upper limit); (4) history of severe kidney disease or serum creatinine & GT; 133 mu mol/l; (5) known diseases of blood system or hemoglobin <90 g/L (9g/dL); (6) hypoproteinemia, serum albumin <35g/L; (7) Blood transfusion or blood donation within the last 3 months; (8) Serious organic diseases, including cancer, coronary heart disease, myocardial infarction or stroke, or cognitive impairment caused by trauma, poisoning, alcoholism, Parkinson's disease, polymyositis, etc.; (9) Assessment of cognitive function affected by severe depression, schizophrenia and other mental diseases or delirium; (10) Infectious diseases, including tuberculosis and AIDS; And alcoholism; (11) Participated in other studies or observational researchers at the same time or within 3 months; (12)Unable to cooperate with the tester for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA score;MMSE score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycosylated albumin;blood glucose; | — |
Countries
China
Contacts
Public ContactShunjiang Xu
The first hospital of Hebei Medical University
Outcome results
None listed