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Study on the upregulation of Fibulin-5 expression by the beneficial Qi elevation method through LTBP-4 and its effect on elastic fiber activity in prolapsed hemorrhoid tissue

Study on the upregulation of Fibulin-5 expression by the beneficial Qi elevation method through LTBP-4 and its effect on elastic fiber activity in prolapsed hemorrhoid tissue

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2100005446
Enrollment
Unknown
Registered
2021-12-26
Start date
2022-01-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

haemorrhoids

Interventions

A: patients with internal hemorrhoids:Melilotus Extract Tablet+Buzhongyiqi Decoction
C: patients with internal hemorrhoids:without intervention
D: pations with low level simple anal fistula:without intervention
B: patients with internal hemorrhoids:Melilotus Extract Tablet

Sponsors

The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were: age 16-65 years old, with no gender limitation; meet the diagnostic criteria of prolapse internal hemorrhoids; conforming to TCM syndrome differentiation; the course of disease is more than half a year; be able to understand the study, cooperate with the study, and complete the follow-up.

Exclusion criteria

Exclusion criteria: Exclusion criteria were: pregnant or lactating women; allergic to the drug; patients with serious primary diseases of cardiovascular, liver and hematopoietic system or mental illness; severe renal impairment; unable to understand the study and complete the follow-up.

Design outcomes

Primary

MeasureTime frame
Symptoms of hemorrhoids;Important genes WB detection;Related fibrin deposition mRNA assay;Important genes mRNA detection;Related fibrin deposition WB assay;Physical examination of hemorrhoids;

Secondary

MeasureTime frame
Blood routine;Electrocardiography;Stool Routine;urine routine;

Countries

China

Contacts

Public ContactSun Feng
458152220@qq.com18138718886

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026