Gout
Conditions
Interventions
Spleen deficiency and dampness resistance group:no
Healthy control group:no
Damp-heat accumulation syndrome group:no
Sponsors
Yunnan Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of case group :(1) meet the diagnostic criteria of primary gout; (2) TCM syndrome differentiation belongs to damp-heat accumulation type or spleen deficiency dampness resistance type; (3) 18-70 years old; (4) Voluntarily participate in the study and sign the informed consent to enter the clinical study; (5) No gastrointestinal diseases, no antibiotics, gastrointestinal drugs or probiotics in the past 2 months; Control group inclusion criteria :(1) non-gout and hyperuricemia; (2) Exclude metabolic diseases, such as diabetes, obesity and hyperlipidemia; (3) No gastrointestinal diseases, no antibiotics, gastrointestinal motility drugs or probiotics in the past 2 months; (4) 18-70 years old; (5) As far as possible from the same region as the case group.
Exclusion criteria
Exclusion criteria: (1) those who have taken antibiotics, probiotics and prebiotics within 2 weeks;(2) Secondary hyperuricemia and gout, such as congenital metabolic disease, myeloproliferative disease, advanced hypertension, diabetic ketoacidosis caused by hyperuricemia, renal failure, tumor chemotherapy and/or radiotherapy, etc.;(3) arthropathy caused by rheumatoid arthritis, suppurative arthritis, traumatic arthritis, psoriatic arthritis, pseudogout, lupus erythematosus and other diseases;(4) Blood creatinine = 133umol/ L;(5) patients with major organ failure or mental illness, tumor and other diseases;(6) Bmi = 50 or alcoholics;(7) pregnant and lactating women;(8) Exclude metabolic diseases, especially those affecting intestinal flora;(9) persons under the age of 18 or over 70;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Routine stool + occult blood test;kidney function (BUN, Cr, UA);urine routine;Tenderness score;Blood Routine Examination;CRP;lesion site X film;electrocardiogram;ESR;blood glucose;Blood lipid;TCM syndrome score;Liver function (ALT, AST);Intestinal flora detection; | — |
Countries
China
Contacts
Public ContactZhaofu Li
Outcome results
None listed