type 2 diabetes mellitus combined with nonalcoholic fatty liver disease
Conditions
Interventions
control group:Conventional western medicine treatment
Experimental group:Conventional western medicine treatment
Sponsors
Shenzhen Hospital of Guangzhou University of traditional Chinese medicine
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) All the patients meet the diagnostic criteria for type 2 diabetes and non-alcoholic fatty liver disease, and HbA1c is less than 10%. (2) Aged between 20-75 years; (3) Liver function is basically normal: AST or ALT < 2.5 times the upper limit of normal, and total bilirubin was normal; (4) The experimental group did not receive oral treatment of diabetes or non-alcoholic fatty liver at least 2 weeks before admission. The control group did not use hypoglycemic drugs or drugs for the treatment of nonalcoholic fatty liver at least 3 days before joining the group; The effects of drugs on metabolism were excluded. (5) All experimental personnel voluntarily participated in the clinical study, signed informed consent and have good compliance.
Exclusion criteria
Exclusion criteria: (1) Those who do not meet the diagnostic criteria and inclusion criteria; (2) Those who cannot carry out the experiment according to the research procedures, including patients with chronic diseases such as cardiovascular and cerebrovascular diseases and mental diseases; (3) Patients treated with insulin; (4) Patients whose condition changes make it difficult to evaluate the effectiveness and safety of the intervention, such as those with severe liver and kidney dysfunction; (5) Allergic constitution or uncomfortable symptoms after taking drugs or a history of drug allergy; (6) Pregnant and lactating women; (7) Patients who participated in other clinical studies in recent 3 months. If any one of the above items is met, it shall not be selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2hPG;untargeted metabolomics;glycosylated hemoglobin;serum lipids;fasting blood sugar; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatty liver grade and disease activity index score;visceral fat;TCM syndrome score; | — |
Countries
China
Contacts
Public ContactChunli Piao
Shenzhen Hospital of Guangzhou University of traditional Chinese medicine
Outcome results
None listed