Sepsis
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 18 years = age =80 years ?. Actual body weight =45kg; ? The estimated length of ICU stay is = 72 hours (4) Sign informed consent
Exclusion criteria
Exclusion criteria: ? Neurosurgery in the last three months (2) Ischemic stroke occurred within the last 3 months (3) Intracranial hemorrhage within the last 3 months (4) Systolic blood pressure =180mm Hg, diastolic blood pressure =110mm Hg, or vasoactive drug infusion was required for more than 12 hours 5) Massive bleeding in the past week ? Abnormal coagulation during screening: INR=2 times the upper limit of normal value, or APTT=2 times the normal value. G. Thrombocytopenia at screening: platelet count =75× 109/L8 ? Other Heparin contraindications (e.g. heparin-induced thrombocytopenia, pregnancy, lactation) Ultrasonography of lower limbs should not be performed (e.g. bilateral above-knee amputation or severe distal lower limb burns). (10) Limited life support, life expectancy = 14 days, or palliative care Contamination (e.g., use of low molecular weight heparin 3 times after admission to ICU) (12) Lack of informed consent (13) Blood products are contraindicated
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D dimer, procalcitonin, thromboregulatory protein, thrombin/antithrombin complex, tissue-type plasminogen activator - activator inhibitor 1 reactivator, plasminase/antiplasminase A2 complex, antithrombin ?;Bleeding and coagulation time;Incidence of proximal deep venous thrombosis of the lower leg;Bedside ultrasound screening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time;28\90-day survival curve;All - cause mortality in hospital;28 - day mortality;Thrombolysis diagram(TEG);The incidence of MODS;Expenses during ICU hospitalization;Length of stay in ICU;Incidence of pulmonary embolism; | — |
Countries
China
Contacts
Public ContactYan Kang
West China Hospital of Sichuan University
Outcome results
None listed