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Application and mechanism of transcutaneous auricular vagus nerve stimulation in disorder of consciousness after brain injury

Application and mechanism of transcutaneous auricular vagus nerve stimulation in disorder of consciousness after brain injury

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100005296
Enrollment
Unknown
Registered
2021-04-07
Start date
2021-04-15
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorder of consiousness

Interventions

Sponsors

Hangzhou normal university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >18years; 2. Subacute patients diagnosed as DOC by CRS-R; 3. No nerve stimulating drugs were used within 48 hours before enrollment; 4. No neuromuscular blocker was used within 24 hours before enrollment; 5. No facial or ear pain, no recent ear trauma, no metal implants, including pacemakers, no pregnancy.

Exclusion criteria

Exclusion criteria: 1. Personal or family history of epileptic seizures, history of cardiovascular disease, history of developmental neurological or psychiatric disease; 2. Untreated brain edema; 3. Metal implants in the body; 4. Unstable vital signs; 5. MRI scan contraindications: such as claustrophobia.

Design outcomes

Primary

MeasureTime frame
Electroencephalogram;Behavior scale;

Secondary

MeasureTime frame
telomere, proteins;Functional magnetic resonance;PET-glucose metabolism;

Countries

China

Contacts

Public ContactCheng Ljuan

Hangzhou Normal University/Qianjiang College

24241598@qq.com+86 571 28861260

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026