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Electroacupuncture combined with extracorporeal shock wave therapy improves pain symptoms and inflammatory factor levels in knee osteoarthritis patients, and promotes articular cartilage repair

The role and mechanism of cGAS/STING sensing DNA damage in initiating cell senescence in degenerative osteoarthritis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100005216
Enrollment
Unknown
Registered
2021-10-09
Start date
2018-08-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Sponsors

Shanghai Tenth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) The diagnostic criteria of KOA conform to American College of Rheumatology (ACR); (2) Kellgren-Lawrence (K-L) staging is stage I, stage II or stage III; (3) The heart, lung, liver, and kidney functions are good, and they can tolerate ESWT; (4) No drugs or knee arthroscopic surgery has been used for treatment in the past 3 months; (5) The informed consent form was signed.

Exclusion criteria

Exclusion criteria: (1) Rheumatoid arthritis, rheumatoid arthritis, traumatic arthritis, gouty arthritis; (2) There is a wound on the affected knee or tuberculosis, infection, osteomyelitis in the affected limb; (3) Suffering from vascular and neurological diseases; (4) The affected knee has severe varus deformity; (5) Combining severe primary diseases such as liver, kidney, cardiovascular and cerebrovascular and hematopoietic systems diseases; (6) With severe osteoporosis; (7) Breast-feeding or pregnant women; (8) Those who cannot tolerate ESWT due to pain and other factors; (9) The content of knee joint fluid is too small to meet the testing needs.

Design outcomes

Primary

MeasureTime frame
ROM;LKSS score;WOMAC scale;Lequesne index score;VAS score;

Secondary

MeasureTime frame
MMP-3;SOD;TNF-a;TGF-ß1;IL-1ß;

Countries

China

Contacts

Public ContactZhong Wu

Shanghai Tenth People's Hospital

wuzhong0515@126.com+86 18917685605

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026