Migraine
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1)Comply with the diagnostic criteria of the International Classification of Headache Disorders III (ICHD-3 beta); 2)18-65 years old, right handedness; 3)A history of migraine for at least 1 year; 4)The frequency of migraine attack more than twice a month; 5)No acupuncture treatment or medication was used within 24 hours after the acute onset of migraine, and no preventive treatment for migraine during the past 3 months; 6)Sign written informed consent.
Exclusion criteria
Exclusion criteria: 1)Other types of primary headaches such as chronic migraine, tension-type headaches, nerve headache and cluster headache; 2)Any other secondary headaches or neurological diseases-headaches caused by intracranial diseases such as otolaryngological diseases, depression and Parkinson's disease; 3)Relatively severe life-threatening diseases, such as cardiovascular diseases, acute infectious diseases, hematological diseases, endocrine diseases, allergies or hemoptysis; 4)Use of prophylactic migraine medication and acupuncture treatment during the past three months. 5)Pregnancy, lactation and preparation for pregnancy; 6)Smoking, alcohol and drug abuse; 7)Patients with pain within 3 days before MR scan; 8)Any contraindications of acupuncture treatment, such as hematological diseases and local infections, etc; 9)Any contraindications for MRI exam, such as metal implants in the body, claustrophobia, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Halving rate of headache days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Migraine disability assessment;Beck depression inventory;Visual analogue scale;Self-rating anxiety scale;Headache impact test-6; | — |