Alzheimer's disease
Conditions
Interventions
Sponsors
Wuhan University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Residents of the community, those who participate in the community elderly physical examination; 2. The age is 65-85 years old; 3. Expected survival period > 1 year; 4. No tumor, congenital or acquired immunodeficiency disease, congestive heart failure, angina pectoris, myocardial infarction, uncontrolled hypertension or arrhythmia and other serious heart diseases, active hepatitis, liver cirrhosis and other serious liver diseases , Any serious kidney disease such as glomerulonephritis, nephrotic syndrome, uremia, etc., without chronic diarrhea; 5. Blood routine and electrocardiogram were in the normal range when entering the group, the upper limit of liver and kidney function measurements was <=1.5 times the normal value, blood pressure systolic blood pressure <160mmHg, diastolic blood pressure <100mmHg; 6. Patients with mild to moderate AD, patients with mild cognitive impairment; 7. Elderly patients with depression; 8. Informed consent of patients or their guardians.
Exclusion criteria
Exclusion criteria: 1. Patients with suicidal tendencies, that is, those with a score of >= 2 on the third item of the Hamilton Depression Scale; 2. Those with a history of drug allergy; 3. Alcoholism and/or psychoactive substances, drug abusers and dependents (including sleeping pills); 4. Those who do not use the prescribed medication, cannot judge the efficacy or incomplete data, etc., which affect the judgment of efficacy and safety; 5. Those who are unable to understand the contents of the scale due to insufficient awareness, language barriers, intelligence and education level (below primary school education); 6. Visual or hearing impairment prevents the test or assessor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical detection index;Psychoaffective assessment;General cognitive tests;Proteomic detection;Cognitive domain test;Imaging Characteristics;Genetic detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric indexes;Family histories;Demographics and socioeconomic position;TCM Constitution Classification;Coating on the tongue;Behavior characteristics;Previous histories;Activities of daily living and basic activities of daily living; | — |
Countries
China
Contacts
Public ContactZeng Yan
Wuhan University of Science and Technology
Outcome results
None listed