Premature ovarian insufficiency(POI)
Conditions
Interventions
Experimental group:Herbal concentrate-granules Huyang Yangkun formula
Control group:Placebo
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of TCM and Western medicine for premature ovarian insufficiency spleen and kidney yang deficiency. 2. Aged between 18-39 years. 3. Clinically abnormal period POI: The obvious incentives are oligomenorrhea (menstrual cycle is more than 35 days), and it lasts for more than 2 consecutive cycles; the natural menstrual period is less than 6 months, and the bFSH of 4 weeks between the two times is greater than 25 U/L. 4. Sex hormone drugs within the past 3 months. 5. Sign the informed consent form, voluntarily participate in the project survey, and answer the survey questions truthfully.
Exclusion criteria
Exclusion criteria: 1. Menstrual disorders caused by congenital hypogonadism and acquired organic diseases; 2. Menstrual disorders caused by endocrine diseases such as polycystic ovary syndrome, hyperprolactinemia, dysfunctional uterine bleeding, hypogonadotropin, hyperthyroidism and other endocrine diseases (disorders); 3. Infertile patients treated with assisted reproductive technology; 4. Abnormal vaginal bleeding within the past 12 months, endometrial biopsy suggests clinically relevant abnormalities, or undiagnosed irregular vaginal bleeding; 5. Suspected cervical cancer or cervical precancerous lesions; suspected breast cancer; known or suspected history of hormone-dependent tumors or malignant tumors; 6. Patients with severe mental illness; clinically considered obvious suicidal tendencies; 7. Uncontrolled and/or diagnosed medical conditions that may interfere with or affect study treatment, for example, severe liver, kidney, heart, or brain disease; uncontrolled or untreated hypertension (systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 100 mmHg); or abnormal thyrotropin may cause symptoms similar to menopause; 8. Pregnant or lactating patients; 9. Those who have participated in other clinical trials in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Greene scale;Estradiol;Follicle stimulating hormone;Menstrual cycle;Luteinizing hormone;Follicle growth and development;Female sexual function index; | — |
Countries
China
Contacts
Public ContactYang Hongyan
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed