Hand-foot-and-mouth disease
Conditions
Interventions
Control group:Conventional therapy
Andrographolide Sulfonate (Xiyanping injection), No.2 Qing Re Jie Du decoction in conjunction with conventional therapy:Andrographolide Sulfonat, No.2 Qing-Re Jie-Du decoction
Sponsors
Beijing Youan Hosptial, Captial Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 5 Years
Inclusion criteria
Inclusion criteria: According the guidelines for the diagnosis and treatment of HFMD issued by the Ministry of Health of China in 2018, the diagnosis of severe HFMD was established. children aged 1-5 years; no more than 24 hours after the occurrence of central nervous system symptoms, such as lethargy and weakness, agitation or irritability, headache, vomiting, limb weakness or acute flaccid paralysis, myoclonic jerks, ataxia, nystagmus, and oculomotor palsies.
Exclusion criteria
Exclusion criteria: The excluded criteria were considered as: patients had neurogenic pulmonary edema or heart or respiratory failure, chronic hepatitis, congenital heart disease, or acute or chronic nephritis; had a history of allergy to herbal medicine, or mild increases in bilirubin, intravascular hemolysis. In addition, patients had been taken Chinese herbal medicines or antivirals, hormonal therapy or participated in other clinical studies on HFMD, and had any condition that could have interfered with the evaluation of the study objectives.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Other Clinic symptoms;Herpes;fever; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of converse to critical condition;Incidence of complications; | — |
Countries
China
Contacts
Public ContactXiuhui Li
Outcome results
None listed