hyperuricemic nephropathy at CKD stages 3-4
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for uric acid nephropathy and TCM syndromes; 2. Age 18-75 years old, with independent behavior ability, no gender limitation; 3. Glomerular filtration rate: 15ml/min<=eGFRCKD-EPI-ASIA<60ml/min; 4. No renal replacement therapy; 5. Sign the informed consent to enter the clinical research.
Exclusion criteria
Exclusion criteria: 1. Those with allergies or allergic constitution to the test drugs and control drugs; 2. Pregnant or lactating female patients; 3. Patients with abnormal liver function (ALT or AST exceeds the upper limit of normal by 2 times or more); 4. Combined with serious primary diseases such as nervous, cardiovascular, digestive, urinary, endocrine and hematopoietic systems, mental patients; 5. Those who are participating in other clinical drug trials; 6. Those who have received similar treatment within 2 weeks before the trial; 7. Patients with uric acid nephropathy with proteinuria (proteinuria>1g/d) or diabetes or hereditary kidney disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary N-acetyl-ß-D-glucosaminidase;Estimated glomerular filtration rate;Urinary ß2-microglobulin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chinese medicine clinical symptom score;Urinary microalbumin-creatinine ratio;24-hour urinary protein quantity;Blood urea nitrogen;Serum uric acid;Serum creatinine;24-hour urine uric acid;Urinary retinol binding protein;Kidney B ultrasound;Nitric oxide; | — |
Countries
China
Contacts
Public ContactGao Jiandong
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed