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Modified Xiaochaihu decoction combined with mirtazapine in the treatment of persistent depression: A pilot randomized controlled trial

Modified Xiaochaihu decoction combined with mirtazapine in the treatment of persistent depression: A pilot randomized controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100005013
Enrollment
Unknown
Registered
2021-07-04
Start date
2018-06-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persistent depressive disorder

Interventions

Sponsors

The Sixth Medical Center of the General Hospital of the People's Liberation Army, Beijing, China
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who meet the diagnostic criteria of PDD in DSM-5 and are accompanied by symptoms of "chronic insomnia" or "pain"; 2. SDS Self-Rating Scale (compiled by W.Zung in 1965, also known as "Zung Self-Rating Depression Scale" is one of the scales recommended by the U.S. Department of Education, Health and Welfare for psychopharmacology research. Because it is simple to use, it can reflect patients' subjective feelings of depression and its changes in treatment intuitively. At present, it has been widely used in outpatient rough screening, emotional state assessment, investigation, scientific research, etc. The total score >=41 points; 3. Aged 24 to 64 years; 4. Those who can correctly understand the content of the scale.

Exclusion criteria

Exclusion criteria: 1. Patients who received other antidepressant treatment within 2 weeks of the beginning of this study; 2. Have a history of alcohol and drug dependence; 3. Pregnant women and lactating women; 4. Instable control of hypertension, diabetes and other chronic internal diseases; 5. abnormal liver and kidney function; 6. Patients with fever, pneumonia, trauma and other diseases.

Design outcomes

Primary

MeasureTime frame
Self-Rating Depression Scale;

Countries

China

Contacts

Public ContactXiuyu Li

The Sixth Medical Center of the General Hospital of the People's Liberation Army, Beijing, China

hzxyee@163.com+86 18600310297

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026