nonalcoholic fatty liver disease (NAFLD)
Conditions
Sponsors
Second Affiliated Hospital of Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Resident aged 18-65 years in Chongqing; 2. No history of drinking or drinking alcohol equivalent to less than 210g/week (women 5.56%) meet the diagnostic criteria of diffuse fatty liver and no other reasons can be explained.
Exclusion criteria
Exclusion criteria: 1. Histological changes of liver biopsy within the past 6 months meet the pathological diagnostic criteria of significant or progressive fibrosis NASH or liver cirrhosis; 2. Taking lipid-lowering drugs (such as statins, fibrates, etc.) and drugs or health products that may affect liver fat content within the past 3 months (such as silibinin, ursodeoxycholic acid, bicyclol, phosphatidylcholine and vitamin E, glucocorticoids, fish oil, etc.); 3. Those with diabetes who have been treated with insulin or who have undergone bariatric surgery for obesity; 4. Patients with severe cardiac insufficiency, liver and kidney insufficiency, malignant tumor, pregnancy and lactation, or women and men who wish to become pregnant or have children during the study; 5. Patients with a history of mental illness who cannot cooperate with the research of this project; 6. There are contraindications to MRI; 7. Possible circumstances that other researchers believe would prevent completion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI liver proton density fat fraction; | — |
Secondary
| Measure | Time frame |
|---|---|
| fasting insulin;glycated hemoglobin;blood lipid;fasting blood sugar;liver function;renal function; | — |
Countries
China
Contacts
Public ContactQin Yu
Second Affiliated Hospital of Army Medical University, PLA
Outcome results
None listed