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A Randomized, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous Xingnaojing for Acute Ischemic Stroke patients with Endovascular Thrombectomy

A Randomized, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous Xingnaojing for Acute Ischemic Stroke patients with Endovascular Thrombectomy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100004970
Enrollment
Unknown
Registered
2021-06-21
Start date
2021-08-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

two groups:Xingnaojing injection 20ml, bid,10 days

Sponsors

Beijing Tiantan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Patients over 18 years old; 2. Acute ischemic stroke was diagnosed 3. MRA or CTA showed occlusion of anterior circulation arteries 4. Acute intravascular therapy (including simple intravascular therapy and bridging therapy) within 24 hours of onset 5. Randomization was completed within 24 hours after operation 6. ICF should be signed by patients or family members

Exclusion criteria

Exclusion criteria: 1.Treated with Xingnaojing injection 2. Patients with transient ischemic attack 3. Patients with cerebral hemorrhage on imaging examination 4. Patients with vasculitis 5. ALTAST = 3 times of the upper limit of normal value, Cr = 2 times of the upper limit of normal value 6. Patients with a tendency of bleeding, and severe bleeding occurred within 3 months 7. Allergic to Xingnaojing, ethanol, glycerin or allergic constitution 8. Patients with pregnancy planning, pregnancy or lactation 9. Patients with severe heart, liver, kidney disease or malignant tumor, life expectancy < 3 months 10. Patients participating in other drug clinical studies 11. The patients who are not suitable for the clinical study (such as those with mental and mental disorders, etc.) are considered by the researchers.

Design outcomes

Primary

MeasureTime frame
good clinical outcomes;

Countries

China

Contacts

Public ContactLiping Liu
lipingsister@gmail.com13331159535

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026