Radiation acute oral mucositis in a patient with nasopharyngeal carcinoma
Conditions
Interventions
Sponsors
Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with locally advanced nasopharyngeal carcinoma diagnosed by pathology and UICC/AJCC TNM staging of stage III and stage A in the 8th edition; 2. Has indications for radical concurrent radiotherapy and chemotherapy, and is scheduled to receive (IMRT technique for radiotherapy, platinum-containing regimen for chemotherapy), and has received radiotherapy for the first time, and has not received surgical treatment; 3. Kanofsky Performance Status (KPS) score >= 70; 4. Blood routine, normal liver and kidney function, and good blood glucose control in diabetic patients (fasting blood glucose 3.9-7.2mmol/L, blood glucose 2 hours after meal <= 10.0mmol/L, HbA1c < 7%); 5. Expected survival of at least 6 months; 6. Age between 18 and 70 years old, male or female; 7. Signing the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant women, lactating women, and women of childbearing age who were unable to obtain effective contraception during the trial; 2. Other established oral mucosal diseases and no previous history of salivary gland diseases; 3. Patients with recurrent or residual nasopharyngeal carcinoma; 4. Complicated with serious heart, liver, kidney, hematopoietic system and nervous system diseases, diabetes mellitus with unsatisfactory blood glucose control and mental disorders; 5. Patients with other malignant tumors; 6. People who are known or suspected to be allergic to the drugs in this study; 7. Other circumstances that the researcher considers not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of RTOGIII grade oral mucosa; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in time and severity of oral mucositis;Pain in oral mucositis;Nutritional risk screening NRS2002; | — |
Countries
China
Contacts
Public ContactZhang Peng
The Tumor Hospital of Sichuan
Outcome results
None listed