Ischemic stroke
Conditions
Sponsors
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45-80 years; 2. Education level >= 6 years; 3. The onset of ischemic stroke within 2 weeks to 6 months; 4. Hachinski ischemia scale score> 4 points; 5. There is at least one cognitive impairment; 6. The basic daily functions are normal, and the daily functions of complex tools can be slightly damaged; 7. The patient has single or multiple cerebral infarction lesions; 8. Volunteer to participate in this trial, the subject or his legal guardian shall sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. White matter lesions with cortical and watershed infarction, hemorrhage, hydrocephalus, and specific causes (such as multiple sclerosis); 2. There are major cognitive dysfunctions (the MMSE score of the Simple Mental State Examination Scale is divided by education level: elementary school 17 points, or patients with depression/severe mental disorders; 7. History of other secondary dementia, epilepsy, etc.; 8. Alcoholism, drug abuse; 9. Accompanied by severe neurological deficits that cannot complete the relevant examinations; 10. Those who have participated in other drug trials within 3 months before being selected; 11. Use other drugs to improve cognitive function such as ChEIs or other psychotropic drugs within the past 3 months; 12. Those who are allergic to the test drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test;Alzheimer's Disease Rating Scale-Cognitive Part; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Diffusivity;Verbal Fluency Test;Montreal Cognitive Assessment;Complex Figure Test;Network Connections;Fractional Anisotropy;Mini-Mental State Examination;Trail Making Test;Symbol Digit Modalities Test;Infarction Volume;Clock Drawing Test;Activities of Daily Living Inventory; | — |
Countries
China
Contacts
Public ContactWang Yanping
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
Outcome results
None listed