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Effect of platelet activating factor receptor antagonist on acute ischemic and its anti-thrombotic and anti-inflammatory mechanism

Effect of platelet activating factor receptor antagonist on acute ischemic and its anti-thrombotic and anti-inflammatory mechanism:a case-control study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100004815
Enrollment
Unknown
Registered
2021-01-24
Start date
2021-02-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

Sponsors

Zhaoqing First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1) Diagnosis of an acute ischemic stroke was confirmed using brain magnetic resonance imaging within the onset time=72 hours; 2) signs and symptoms of neurological deficit, and duration > 6 hours; 3) National Institutes of Health Stroke Scale (NIHSS) score of patient at admission >= 3; 4) Age:18 to 90 years-old.

Exclusion criteria

Exclusion criteria: 1) Intracranial hemorrhagic identified by admission computed tomography (CT) scan or bleeding tendency; 2) Platelet count 450 x 10^9/L in the peripheral blood; 3) Coexisting severe systemic diseases, including severe heart diseases, hepatic and renal insufficiency, cancers, blood diseases or autoimmune diseases; 4) Major surgery in recent 4 weeks; 5) History of using other non-steroidal anti-inflammatory drugs, such as cilostazol, dipyridamole, warfarin, new oral anticoagulant drugs (NOACs) and low molecular weight heparin; 6) Administration of intravenous thrombolysis or/and intra-arterial thrombectomy treatment; 7) Ginkgo diterpene lactones contraindications.

Design outcomes

Primary

MeasureTime frame
early neurological function deterioration;neurological function at 90 day;

Secondary

MeasureTime frame
Intracranial hemorrhagic transformation;ischemic stroke recurrent;

Countries

China

Contacts

Public ContactXiaoyan Han

Zhaoqing First People's Hospital

xiangyaren@126.com+86 13580648028

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026