Endometrial Cancer and Endometrial Atypical Hyperplasia
Conditions
Sponsors
Obstetrics and Gynecology Department, Peking University People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Aged <= 40 years, have strong desire to have children; (2) atypical hyperplasia of uterus, endometrial cancer progesterone treatment remission; (3) endometrial cancer iag1-iag2 stage, endometrial atypical hyperplasia; (4) imaging examination confirmed that the tumor was confined to the endometrium; (5) estrogen and progesterone receptor (ER, PR) were positive; (6) peripheral blood CA125; (7) no contraindication of progesterone treatment; (8) evaluation of reproductive function before treatment, no other factors of fertility disorders; (9) after complete remission, when the dominant follicle in follicular phase reached 15 mm, the endometrial thickness was less than 7.0 mm; (10) acupuncture treatment was used to improve the endometrial receptivity after preserving reproductive function; (11) informed consent was signed, and good follow-up conditions were available.
Exclusion criteria
Exclusion criteria: (1) Patients with severe medical diseases and severe impairment of liver and kidney function; (2) patients with endometrioid adenocarcinoma whose pathological stage or grade is higher than stage IA G1, or with deep myometrial invasion, cervical invasion or distant metastasis in pelvic and abdominal cavity; (3) patients with drug allergy and contraindications; (4) patients with other types of endometrial cancer or other malignant tumors of reproductive system; patients with breast cancer or other malignant tumors He can not use progesterone hormone dependent tumor; (5) require hysterectomy or other methods of treatment except conservative treatment; (6) deep vein thrombosis, stroke, myocardial infarction; (7) allergic constitution or allergic to acupuncture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index;Endometrial morphology;Anxiety and depression assessment;Early spontaneous abortion rate;Live birth rate;Preterm birth rate;Available embryo rate;Recurrence rate;High quality embryo rate;Incidence rate of complications during pregnancy;Endometrial peristalsis;Clinical pregnancy rate;Egg rate;Embryo implantation rate;Endometrial blood flow;Relapse free survival; | — |
Countries
China
Contacts
Public ContactQun Lu
Peking University People's Hospital
Outcome results
None listed