knee osteoarthritis/diarrhea-predominant irritable bowel disease
Conditions
Interventions
Sponsors
Mianyang Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with KOA: 1. Meeting the ACR diagnostic criteria for KOA; 2. Having the typical symptoms of KOA; 3. Age above 18 years, regardless of gender; 4. Voluntarily accept treatment; 5. Good compliance and willingness to cooperate with the study, with the patient signing an informed consent form. Inclusion criteria for patients with IBS-D: 1. Those who meet the above diagnostic criteria for IBS-D Rome IV; 2. Having the typical symptoms of IBS-D; 3. Age above 18 years, regardless of gender; 4. Voluntary treatment; 5. Good compliance and willingness to cooperate with the study, with the patient signing an informed consent form; 6. Lack of morphological changes and biochemical abnormalities that could explain the symptoms; 7. Those who have not received acupuncture treatment for IBS in the last 3 months prior to entering treatment.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with KOA: 1. Patients with concomitant non-primary osteoarthritis such as rheumatoid arthritis, bone tumours, bone tuberculosis, etc; 2. Patients following knee replacement; 3. Patients who are afraid of needles, prone to needle fainting or whose needling sites are prone to bleeding, infection, ulceration or scarring; 4. Patients with a combination of serious primary illnesses such as heart, lung, liver, kidney or other major diseases; 5. Patients with mental disorders and intellectual disabilities who are unable to cooperate; 6. Patients with bleeding tendencies, allergies, scars and other skin diseases; 7. Pregnant or lactating women, those with severe skin lesions who are otherwise unsuitable for acupuncture; 8. Those who are participating in other clinical trials. Exclusion criteria for patients with IBS-D: 1. Those who meet the diagnostic criteria of IBS-C, IBS-M, IBS-U Rome IV; 2. Those with organic lesions of the intestinal tract or systemic diseases that affect the dynamics of the digestive tract (e.g. cholecystitis, pancreatitis, hyperthyroidism, chronic renal insufficiency); 3. Those who are afraid of needle, prone to needle fainting or those who are prone to bleeding, infection, ulceration or scarring at the site of needling; 4. Those with a history of abdominal or rectal anal surgery; 5. Those who regularly take drugs or inhibitors that affect gastrointestinal dynamics or alter intestinal function; 6. Persons with a combination of serious primary illnesses such as heart, lung, liver, kidney or other major diseases; 7. Patients with mental disorders and intellectual disabilities who are unable to cooperate; 8. Patients with bleeding tendencies, allergies, scars and other skin diseases; 9. Pregnant or lactating women, those with severe skin lesions who are otherwise unsuitable for acupuncture; 10. Those who are participating in other clinical trials, or refuse to be enrolled for observation or contain other unstable factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum microRNA199; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale(VAS);Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC);the MOS item short from health survey(SF-36);IBS-SSS; | — |
Countries
China
Contacts
Public ContactLi Sihui
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed