mild Cognitive impairment in cerebral Small Vessel Disease (the De-CSVD study)
Conditions
Interventions
Sponsors
Shandong Second Provincial General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 50-70 years; 2.There is a decline in cognitive ability in memory or other cognitive areas, which lasts for at least 3 months, which is in line with the "Chinese Diagnosis and Treatment Guidelines for Cognitive Dysfunction Related to Cerebral Vascular Disease (2019)" of the Geriatric Neurology Group of the Chinese Medical Association Geriatrics Branch Diagnosis criteria for degree cognitive impairment: (1) Cognitive decline in one or more cognitive functional domains; (2) Cognitive dysfunction is insufficient to affect life independence; 3.The MOCA score was less than 26, which did not meet the diagnostic criteria of dementia in (DSM-4) 9, and the clinical dementia rating scale (CDR) score was 0.5 points; 4.There are new small subcortical infarcts, lacunae, white matter hyperintensity, enlarged perivascular space, and cerebral microhemorrhage on CT or MRI of the skull. Chinese Diagnostic and Treatment Guidelines for Cognitive Dysfunction (2019) and the Chinese Consensus on the Diagnosis and Treatment of Cerebral Small Vascular Diseases by the Chinese Medical Association Neurology Branch: (1) There are more than 2 lacunar infarcts outside the brain stem; (2) White matter hyperintensity: Fazekas score >= 2 points; (3) Cerebral micro hemorrhage: number >= 3; 5.Before the operation or examination related to the protocol, the subjects must sign the written informed consent of medication.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage or heavy bleeding from other organs; 2. There was a history of new stroke within 3 months before enrollment; 3. Alcohol or drug abusers; 4. Central nervous system diseases such as Alzheimer's disease, Lewy body dementia, frontotemporal dementia, brain tumors, hydrocephalus, etc. exist. 5. Failure to complete neuropsychological tests and MRI examinations; 6. Participated in other clinical trials within 30 days before the screening visit of this study; 7. The researcher believes that it is impossible for the subject to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| High sensitivity C-reactive protein level;Shape Connection Test (STT);Interleukin-6(IL-6);Plasma D-dimer level;Activity of Daily Living Ability Assessment Scale (ADL);Homocysteine level (Hcy);Dizziness Evaluation Scale (DHI);Geriatric Depression Scale;New vascular events; | — |
Countries
China
Contacts
Public ContactZhang Qinghua
Shandong Second Provincial General Hospital
Outcome results
None listed