Sepsis
Conditions
Interventions
Sponsors
Beijing University of Chinese Medicine Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of sepsis; 2. Combined with gastrointestinal dysfunction; 3. Meet the diagnostic criteria of TCM Yang deficiency syndrome; 4. Aged between 18-80 years; 5. Patients or family members sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Primary digestive tract inflammation; 2. Patients with intestinal dysfunction after gastrointestinal surgery; 3. Patients with advanced tumor; 4. Patients with primary heart, liver, kidney, brain, and blood system serious basic diseases; 5. Contraindications to enteral nutrition; 6. Intolerant to acupuncture; 7. Those who have been admitted to the ICU for less than 4 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum index detection of intestinal mucosal barrier function (serum I-FABP, ZO-1, Occludin, LPS levels);Gastrointestinal dysfunction score (fasting, reflux, gastrointestinal decompression, gastric retention, abdominal distension, abdominal pain, diarrhea, weakened bowel sounds, disappearance of bowel sounds, and constipation);Immunological index detection (peripheral blood CD4+, CD8+, Treg, Th17 cells, serum IL-10);Traditional Chinese Medicine Syndrome Scores;Serum inflammatory factor detection (TLR-4, NF -?B, IL-6);Routine evaluation index of sepsis (PCT, CRP);Colony count of intestinal flora; | — |
Countries
China
Contacts
Public ContactPeng Xiaohong
Beijing University of Chinese Medicine Shenzhen Hospital
Outcome results
None listed