Non-erosive reflux disease
Conditions
Interventions
Sponsors
Fangshan Hospital of Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the syndrome of stagnated heat in liver and stomach and syndrome of qi stagnation and phlegm stagnation syndrome: (1) Western medicine diagnosis is consistent with non-erosive reflux disease; (2) TCM syndrome differentiation refers to the syndrome of stagnated heat in liver and stomach and the syndrome of qi stagnation and phlegm stagnation; (3) Those aged between 18 and 65 years old; (4) Anyone who voluntarily participates in and signs the informed consent form. 2. Inclusion criteria of normal control group: (1) Healthy people (18–65 years old) with mild constitution in TCM and body mass index (BMI) of 18.5–23.9 (The diagnostic criteria of mild constitution refer to Classification and Determination of Constitution in TCM issued in 2009); (2) There is no infectious disease or inflammation after medical examination.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the syndrome of stagnated heat in liver and stomach and syndrome of qi stagnation and phlegm stagnation syndrome: (1) Pregnant women or women preparing for pregnancy and lactating women; (2) Those with allergic constitution and allergy to multiple drugs; (3) Patients with severe primary diseases such as liver, kidney, hematopoietic system, endocrine system and mental illness; (4) Severe cases requiring emergency treatment; (5) Those who participated in other clinical trials within three months. 2. Exclusion criteria for normal control group: (1) There are hepatitis, syphilis, HIV, schistosomiasis and other known infectious diseases; (2) Has a history of gastroesophageal reflux disease; (3) Acute gastroenteritis in recent 6 months; (4) Taking antibiotics in the past three months; (5) Nearly 6 months to infectious disease epidemic area; (6) Nearly 6 months have smelting tour high risk sex life history; (7) Gastrointestinal bleeding in the past three months; (8) Constipation in recent 3 months; (9) Laxatives and weight-loss drugs have been used in the past three months; (10) Nearly three months after taking hormones and other immunosuppressive agents; (11) Gastrointestinal polyposis, malignant tumor; (12) Diabetes, hypertension, coronary heart disease and other chronic diseases; (13) Liver cirrhosis and autoimmune diseases; (14) Chronic obstructive pulmonary disease; (15) Severe food allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tongue coating flora 16SrRNA gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom scale; | — |
Countries
China
Contacts
Public ContactJia Boyi
Fangshan Hospital of Beijing University of Chinese Medicine
Outcome results
None listed