Alzheimer's disease
Conditions
Interventions
Sham Electropuncture plus donepezil group:Sham Electropuncture(3 times/w) + donepezil(5mg, Qd)
Electropuncture plus donepezil group:Electropuncture(3 times/w) + donepezil(5mg, Qd)
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: This study is designed to include participants aged 50-80 years with diagnosis of mild AD according to NIA-AA criteria or with a CDR score between 0.5 and 1. The subject included are required to have no history of taking anti-dementia drugs systematically (donepezil excluded), and at least one reliable caretaker who can accompany the subject during treatment is also needed.
Exclusion criteria
Exclusion criteria: Individuals will be excluded if they have dementia caused by other diseases other than AD, such as cer-ebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; a history of psychological disorders (DSM-IV criteria); uncorrectable visual or auditory impairment that hampers the completion of related examination. Patients could not participate this study if they are allergic to acupuncture or pace-maker installed. Pre-menopausal women will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's disease Assessment Scale-Cognitive Subscale; | — |
Secondary
| Measure | Time frame |
|---|---|
| functional Magnetic Resonance Imaging, fMRI;Activities of Daily Living Scales;magnetoencephalography, MEG; | — |
Countries
China
Contacts
Public ContactWang Gang
Outcome results
None listed