chronic heart failure
Conditions
Interventions
Sponsors
Guang'anmen Hospital, China Academy of Chinese Medicine Science
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age from 30 to 80, gender unlimited; (2) It meets the diagnostic criteria for CHF; (3) Urine N-acetyl-ß-D-glucosaminosidase (NAG) > 12U/L, and estimated glomerular filtration rate (EGFR) BBB> mL /min/1.73m2; (4) It meets the diagnostic criteria of the syndrome of insufficiency of spleen and Yang; (5) the cardiac function class (NYHA) II - III; (6) Signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Heart failure caused by valvular heart disease, congenital heart disease, myocarditis, cardiomyopathy, etc.; (2) People who have been diagnosed with kidney disease; (3) Severe arrhythmias, including frequent premature ventricular beats, grade II type II atrioventricular block, grade III atrioventricular block, and cardiogenic shock; (4) Patients with severe hypertension and poor medication control (SBP >= 180mmHg and/or Diastolic blood pressure >= 110mmHg); (5) Patients with severe liver function abnormalities (ALT or AST reaching more than 3 times the upper limit of normal value), endocrine diseases, malignant tumors and autoimmune diseases; (6) Pregnant or lactating women; (7) People with allergic constitution and drug components in this study; (8) Participating in other clinical trials or participating in clinical trials of other drugs for less than one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NAG; | — |
Secondary
| Measure | Time frame |
|---|---|
| KIM-1;IgG;IGFBP7;LVEF;BUN;RBP;mALB;ß2-MG;a1-MG;Tf;Scr;NGAL;NT-proBNP;TIMP-2; | — |
Countries
China
Contacts
Public ContactSong Qingqiao
Guang'anmen Hospital, China Academy of Chinese Medicine Science
Outcome results
None listed