Vascular Demantia
Conditions
Sponsors
Shenzhen TCM Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 50 years old and = 7 points. 3.Clinical dementia scale (CDR) score >= 0.5,Montreal Cognitive Assessment scale (MoCA) score = 7; 4. He hasn't taken any drugs for dementia in 42 weeks. 5. Voluntarily and sign informed consent, with good compliance.
Exclusion criteria
Exclusion criteria: 1.Dementia caused by Alzheimer's disease or other causes diagnosed by DSM-5 standard. 2. Patients with 2HIS score 17. 4.Patients with severe medical diseases or severe neurological impairment, such as malignant tumors, various aphasia, visual and auditory disorders, etc.; patients with liver, kidney or heart diseases, including those with ALT or AST more than 3 times normal, cardiac function grade 2-4, serum creatinine (Scr) > 177 umol / L; patients with cognitive impairment, such as tumors, AIDS, hyperthyroidism, and patients with severe anemia. Patients with unstable control of metabolic diseases; patients with underlying diseases such as asthma or chronic lung disease, or patients with polyneuritis, myasthenia gravis and muscular atrophy who may have sudden asphyxia; patients with severe gastrointestinal diseases or diseases that affect drug absorption, such as severe dyspepsia, gastrointestinal obstruction, duodenal ulcer, etc.; patients with glaucoma that affect visual function evaluation. Have a history of epilepsy and encephalitis, and related diseases that lead to dementia, such as Huntington's disease, Parkinson's disease, etc.; patients who interfere with the evaluation of cognitive diseases, such as alcoholism, previous drug abuse and drug abusers; patients with severe neurological deficiency with impact evaluation; patients whose heart rate is not in the range of 50-110 beats / min and have developed heart diseases such as myocardial infarction and arrhythmia within 4 months. The systolic blood pressure of patients in sitting position and supine position was not in the range of 100-180 mm Hg. 5. The age of the patients is less than 50 years old, or the course of disease is not enough. 6. Those who had a history of drug allergy or participated in other drug trials within 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| SDSVD; | — |
Countries
China
Contacts
Public ContactGuo Zhouke
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed