acute bronchitis
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of acute trachea-bronchitis; 2. Phlegm-heat obstructing lungs syndrome in traditional Chinese medicine 'Zheng'; 3. Total cough symptom score >=4 points; 4. Expectoration in traditional Chinese medicine symptom score >=6 points; 5. Bronchitis severity score>=6 points; 6. Disease course within 72 hours; 7. Aged 18 to 65 years old; 8. Voluntarily provide written and informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with respiratory diseases such as chronic obstructive pulmonary disease, bronchiectasis, asthma, lung cancer, tuberculosis, pneumonia, lung abscess and chest X-ray showing lung inflammation lesions; 2. Patient with severe underlying cardiac, cerebral, hematological, hepatic or renal disorders or other diseases significantly affecting the survival and prognosis, such as cancer; 3. Current smokers or recent ex-smokers quitting smoking less than 1 month ago; 4. Use of an angiotensin-converting-enzyme inhibitor in the last 1 month 5. Patients with body temperature>=38.5 degree C; 6. ALT or AST>1.5 ULN, urine protein>+, serum creatine abnormality, white blood cell count10x10^9/L, and or neutrophil granulocyte>80%, or those who need antibiotic therapy; 7. Those who have used other medicines after disease onset including antibiotics, expectorants, antitussives, systemic or inhaled corticosteroids, inhaled bronchodilators, Chinese medicines of relieving exterior syndrome with pungent-cool drugs, clearing away heat and detoxification and other related Chinese medicines; 8. Pregnant or lactating women and those who have pregnancy plans in the last 3 months; 9. Allergic constitution or known to be allergic to any ingredients in tested drug; 10. Mental patients or legal disability; 11. Patients who have participated or are currently participating in another clinical trial in the last one month; 12. Patients who are inappropriate for participation judged by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough resolution rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of bronchitis severity scores from baseline to post-treatment;Cough relief rate;Change of TCM syndrome score from baseline to post-treatment;Resolution rate of single TCM symptom;Combination medication use;Time to cough relief;Time to cough resolution; | — |
Countries
China
Contacts
Public ContactBing Mao
West China Hospital, Sichuan University
Outcome results
None listed