Chronic kidney disease
Conditions
Interventions
experimental group:Prescription for warming kidney Yang combined with standardized western medications
control group:Placebo for warming shenyang with standardized western medications
Sponsors
Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to participate in the clinical trial and sign the informed consent; 2. Subjects meeting the diagnostic criteria of chronic kidney disease; 3. Patients with nephrotic syndrome, chronic nephritis syndrome, diabetic nephropathy, IgA nephropathy, membranous nephropathy, focal segmental sclerosing glomerulonephritis, etc; 4. EGFR > 29ml / (min · 1.73m2) in patients with chronic kidney disease (CKD) stage 1-3; 5. Patients with kidney yang deficiency syndrome in TCM; 6. Patients aged 18-75 years old, regardless of gender.
Exclusion criteria
Exclusion criteria: 1. Patients with acute kidney injury in recent one month; 2. Patients with acute infectious diseases, active or delayed chronic hepatitis B, decompensated cirrhosis and active tuberculosis; 3. Patients with serious cardiovascular and cerebrovascular diseases, lung and liver diseases and other primary diseases, or mental diseases; 4. Patients with unstable vital signs and severe electrolyte disorder, or have received renal replacement therapy; 5. Patients with active gastrointestinal bleeding, severe thrombocytopenia, coagulation dysfunction and other hematological diseases in recent 3 months; 6. Patients with other diseases requiring long-term use of other traditional Chinese medicine preparations for more than 4 weeks; 7. Those patients whose aspartate aminotransferase and alanine aminotransferase are 1.5 times higher than the normal value; 8. Pregnant women, lactating women or women with pregnancy plans in the near future; 9. Those subjects with allergic constitution are known or suspected to be allergic to the test drug and its excipients; 10. Subjects who have participated in or are participating in other clinical trials in recent 3 months; 11. Subjects considered unsuitable by the researchers to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Twenty-four hours urinary protein content;urine albumin-creatinine ratio;TCM syndrome Rating Scale;Glomerular filtration rate;Serum creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| albumin;Blood uric acid;hemoglobin;total protein;Blood urea nitrogen; | — |
Countries
China
Contacts
Public ContactZongjiang Zhao
Beijing University of Chinese Medicine
Outcome results
None listed