rheumatoid arthritis
Conditions
Interventions
Sponsors
The Affiliated Hospital of Yunnan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meet the 2010 ACR/EULAR diagnostic criteria for RA; (2) It conforms to the diagnostic criteria of WP liver and kidney deficiency syndrome; (3) It met the diagnostic criteria of osteopenia based on DXA measurement results; (4) Age between 18 and 70, gender is not limited; (5) DAS28 score < 5.1; (6) Volunteered to take the test and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Severe joint deformity, the classification of the activities and functions of III level or above; (2) Have taken drugs affecting bone metabolism within 3 months, such as glucocorticoids, cyclosporine A, bisphosphonates, antiepileptic drugs, tumor chemotherapies, thyrosteroids, estrogen progesterone, etc.; (3) Suffer from other diseases that may be secondary to osteoporosis, such as: endocrine diseases (Cushing syndrome, hyperthyroidism, type I diabetes), hematologic diseases (leukemia, systemic mastocytosis, etc.), chronic renal failure, etc.; (4) Patients with primary osteoporosis; (5) Complicated with other rheumatic immune diseases, or heart, liver, kidney and other important viscera diseases, or complicated with various acute or chronic infections or other infectious diseases; (6) Have a history of contraindications and allergies to experimental drugs; (7) Have a history of alcohol abuse, drug abuse or neuropsychiatric disorders (epilepsy, depression, etc.); (8) Pregnant or lactating women who have a recent birth plan; (9) Participating in clinical studies of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM syndrome score;Hip bone mineral density measured by DXA;Therapeutic Effect of TCM Diseases;DAS28 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score for the degree of pain assessed by the patient;cytokines;PINP;CRP;D-MID;OPG;Morning stiffness time;RF parting;ESR;Number of joint tenderness;HAQ;measurement of T lymphocyte subsets;Joint swelling number;ALP;ß-CTX;The patient assessed the overall condition of the disease VAS score;CCP;Improved Sharp Score;The overall condition VAS score for the disease was assessed by the researchers;Blood electrolyte;11/5000 ACR20 compliance rate; | — |
Countries
China
Contacts
Public ContactXiaohu Tang
Yunnan Traditional Chinese Medicine Hospital
Outcome results
None listed