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Study on intestinal microecological environment and intervention effect of 'phlegm dampness constitution NAFLD' population based on metagenomics

Study on intervention effect and intestinal environment of 'phlegm dampness constitution NAFLD' population based on metagenomics

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100004286
Enrollment
Unknown
Registered
2020-10-19
Start date
2020-10-30
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease

Interventions

Sponsors

The Second Affiliated Hospital of Shandong University of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients aged 20-50 years old; 2. Patients who meet the criteria of mild constitution and phlegm dampness constitution respectively; 3. Patients who have lived in Jinan for more than one year and have not taken antibiotics and other drugs within one month; 4. Patients who have no major disease and have the ability to cooperate with the completion of this trial; 5. "Phlegm dampness constitution NAFLD" population should meet the following three conditions at the same time: (1) There was no history of alcohol drinking or the equivalent alcohol consumption was less than 140g / week (female less than 70g / week); (2) Except viral hepatitis, drug-induced liver disease, total parenteral nutrition, hepatolenticular degeneration, autoimmune liver disease and other specific diseases that can lead to fatty liver; (3) The histological changes of liver biopsy were consistent with the pathological diagnostic criteria of fatty liver disease. In view of the difficulty in obtaining liver histological diagnosis, NAFLD was defined as: No history of drinking; The imaging findings of the liver were consistent with the diagnostic criteria of diffuse fatty liver, and there was no other reason to explain.

Exclusion criteria

Exclusion criteria: 1. Patients taking various drugs or receiving other treatments; 2. Patients with other diseases such as severe hypertension and organic heart disease; 3. Pregnant, menstrual and lactating women.

Design outcomes

Primary

MeasureTime frame
score of constitution;blood lipids;

Secondary

MeasureTime frame
BMI;blood pressure;B-can;

Countries

China

Contacts

Public ContactTiefeng Zhang

The Second Affiliated Hospital of Shandong University of traditional Chinese Medicine

tiefeng89@163.com+86 13869142608

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026