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To explore the mechanism of acupuncture treatment on prethrombotic state of repeated implant failure based on microrna-451a regulating IL6 / STAT pathway

To explore the mechanism of acupuncture treatment on prethrombotic state of repeated implant failure based on microrna-451a regulating IL6 / STAT pathway

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2100004266
Enrollment
Unknown
Registered
2021-01-14
Start date
2021-02-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

repeated implantation failure

Interventions

Sponsors

Fujian Maternity and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (l) Patients who meet the diagnostic criteria of Western medicine and traditional Chinese medicine; (2) After oocyte retrieval, the patients who have obtained the embryo quality of 1-2 grade; (3) The age ranged from 20 to 40 years old.

Exclusion criteria

Exclusion criteria: (1) Organic diseases or other endocrine diseases were excluded: female genital malformations, including uterine malformations (single horn uterus, bicornate uterus, mediastinal uterus and double uterus), adenomyosis, submucosal myoma and intrauterine adhesions, etc.; reproductive endocrinopathy and autoimmune diseases such as hyperprolactinemia and thyroid dysfunction; (2) Patients with primary diseases such as liver and kidney, cerebrovascular, cardiovascular and hematopoiesis disorders, psychotic patients, allergic to aspirin or other salicylates or other components of drugs, patients with history of gastric and duodenal ulcer or gastrointestinal bleeding or other situations where aspirin is prohibited; (3) Incomplete data affect the judgment; (4) Those who can't adhere to the course of treatment, drop out or lose the interview; (5) In the experiment, serious complications occurred.

Design outcomes

Primary

MeasureTime frame
Microrna-451a, Jak and stat gene transfer levels;Safety inspection index;TCM symptom score;Coagulation related indicators;Serum Jak and STAT protein levels;

Countries

China

Contacts

Public ContactYou Xiumi

Fujian Maternity and Child Health Hospital

657932550@qq.com+86 18060840071

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026